Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms.

@article{Doerrler1994CytokinesIC,
  title={Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms.},
  author={William Doerrler and Kenneth R. Feingold and Carl Grunfeld},
  journal={Cytokine},
  year={1994},
  volume={6 5},
  pages={
          478-84
        }
}
Previous studies have demonstrated that some cytokines induce a coordinate catabolic response in adipose cells which leads to decreased fat storage. The mechanisms by which cytokines cause these effects are unknown. The primary purpose of the present study was to determine the effects of TNF, IL-1, IFN-alpha and IFN-alpha on the mRNA levels of the key enzymes involved in fat metabolism in 3T3-F442A adipocytes. TNF, IL-1, IFN-alpha and IFN-gamma decreased lipoprotein lipase activity and… CONTINUE READING
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