Cytokines in the management of rotavirus infection: A systematic review of in vivo studies

@article{Gandhi2017CytokinesIT,
  title={Cytokines in the management of rotavirus infection: A systematic review of in vivo studies},
  author={Gopalsamy Rajiv Gandhi and Victor Santana Santos and Marina Denadai and Valdete Kaliane da Silva Calisto and Jullyana de Souza Siqueira Quintans and Ana Mara de Oliveira e Silva and Adriano Antunes de Souza Ara{\'u}jo and Narendra Narain and Luis Eduardo Cuevas and Lucindo Jos{\'e} Quintans J{\'u}nior and Ricardo Queiroz Gurgel},
  journal={Cytokine},
  year={2017},
  volume={96},
  pages={152–160}
}
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The Complex Interactions Between Rotavirus and the Gut Microbiota
TLDR
Research findings to date related to HRV vaccine cohorts, studies of natural infection, explorations of RV-microbiota interactions in gnotobiotic pig models, and various in vivo and in vitro models that could be used in future studies to better define how the microbiota may regulate RV infection and host antiviral immune responses are detailed.
Antiviral activities of resveratrol against rotavirus in vitro and in vivo.
Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus-induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway.
TLDR
The study revealed that M. cordata exerted antiviral and anti-inflammatory effects on rotavirus-induced diarrhea by suppressing the Janus kinase 2/STAT3 pathway, as reflected by decreased protein expression of phosphorylated (p)-JAK2 and p-STAT3.
Efficacy of adjuvant zinc gluconate therapy for infantile rotavirus enteritis diarrhea
TLDR
Study on rotavirus enteritis in recent years has shown that the deficiency of a variety of trace elements in the children is closely related to the disease deterioration, zinc is of important value for maintaining the integrity of the intestinal epithelial cellular structure and function, and zinc deficiency is closelyrelated to the progression of rotav virus enteritis.
Reduction in Severity of All-Cause Gastroenteritis Requiring Hospitalisation in Children Vaccinated against Rotavirus in Malawi
TLDR
The findings provide additional evidence of RV1 impact in a high disease burden, low-income country, lending further support to rotavirus vaccine programme in Malawi.
Supplementation With 2′-FL and scGOS/lcFOS Ameliorates Rotavirus-Induced Diarrhea in Suckling Rats
TLDR
It could be a good strategy to add a specific human milk oligosaccharide, 2′-fucosyllactose, in combination to infant formulas, to protect against human RV-induced diarrhea in children.
Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture With Bifidobacterium breve M-16V in a Model of Multiple Rotavirus Infections
TLDR
A daily supplement of the products tested in this preclinical model is highly effective in preventing RV-induced diarrhea but allowing the boost of the early immune response for a future immune response against reinfection, suggesting that these components may be potential agents for modulating RV infection in infants.
Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes
TLDR
The results of this work confirm that new immunobiotic strains with the ability of stimulating both local and distal antiviral immune responses can be efficiently selected by evaluating the expression of biomarkers in PIE cells.
Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection
TLDR
It is hypothesized that the FFIG35 or FFIG58 strains could be used for the development of highly efficient functional feed to improve immune health status and reduce the severity of intestinal infections and superinfections in weaned piglets.
Nutrition, Immunity and Viral Infections
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