Cytokines in the management of rotavirus infection: A systematic review of in vivo studies

@article{Gandhi2017CytokinesIT,
  title={Cytokines in the management of rotavirus infection: A systematic review of in vivo studies},
  author={Gopalsamy Rajiv Gandhi and Victor Santana Santos and Marina Denadai and Valdete Kaliane da Silva Calisto and Jullyana de Souza Siqueira Quintans and Ana Mara de Oliveira e Silva and Adriano Antunes de Souza Ara{\'u}jo and Narendra Narain and Luis Eduardo Cuevas and Lucindo Jos{\'e} Quintans J{\'u}nior and Ricardo Queiroz Gurgel},
  journal={Cytokine},
  year={2017},
  volume={96},
  pages={152–160}
}

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References

SHOWING 1-10 OF 67 REFERENCES
Medicinal plants and natural molecules with in vitro and in vivo activity against rotavirus: A systematic review.
Antiviral Effects of Cyclosporin A in Neonatal Mice With Rotavirus-Induced Diarrhea
TLDR
CsA can inhibit rotavirus infection in neonatal mice through its antiviral properties through CsA suppression of inflammation by viral inhibition in animal models.
Effect of human rotavirus vaccine on severe diarrhea in African infants.
TLDR
Human rotvirus vaccine significantly reduced the incidence of severe rotavirus gastroenteritis among African infants during the first year of life.
Protective effects of Lactobacillus rhamnosus GG against human rotavirus-induced diarrhoea in a neonatal mouse model.
TLDR
The results indicated that RV-infected mice developed diarrhoea, accompanied by increased secretion of intestinal mucosa sIgA and serum interferon (IFN)-γ, tumour necrosis factor (TNF)-α, as well as decreased serum IgA.
Cytokines as Mediators for or Effectors against Rotavirus Disease in Children
TLDR
It is suggested that certain cytokines may play an important role in the pathogenesis of and the protection against rotavirus disease in children and, consequently, may provide directions and insights that could prove critical to the prevention or treatment of this important disease.
Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea
TLDR
Anti-rotaviral efficacy of Glycyrrhiza uralensis extract (GUE) as an effective and cheaper remedy without side-effects was evaluated and therapy of this herbal medicine can be a viable medication for curing rotaviral enteritis in animals and humans.
Cyclosporin A Inhibits Rotavirus Replication and Restores Interferon-Beta Signaling Pathway In Vitro and In Vivo
TLDR
Both in vitro and in vivo findings suggest that CsA, through modulating the expression of key regulators in IFN signaling pathway, promote type I IFN-based intracellular innate immunity in RV host cells.
The epithelial cell response to rotavirus infection.
TLDR
It is determined that rotavirus infection of HT-29 intestinal epithelial cells results in prompt activation of NF-kappaB (<2 h), STAT1, and ISG F3 (3 h).
Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model
TLDR
Results indicate that L. ruminis SPM0211, B. longum SPM1205 and 1206 efficiently inhibit rotavirus replication in vitro and in vivo, the first report of L. Ruminis with antiviral activity.
Lactobacillus rhamnosus GG on Rotavirus-Induced Injury of Ileal Epithelium in Gnotobiotic Pigs
TLDR
LGG is moderately effective for ameliorating rotavirus diarrhea by partially preventing injuries to the epithelium and maintained the anti-inflammatory cytokine transforming growth factor-&bgr; level in serum after HRV infection.
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