Cytokines in the central nervous system: regulatory roles in neuronal function, cell death and repair.

@article{Sei1995CytokinesIT,
  title={Cytokines in the central nervous system: regulatory roles in neuronal function, cell death and repair.},
  author={Yoshitatsu Sei and Ljubi{\vs}a Vitkovi{\'c} and Mitchel Mitsuo Yokoyama},
  journal={Neuroimmunomodulation},
  year={1995},
  volume={2 3},
  pages={121-33}
}
Recent evidence suggests that neurons and glia can synthesize and secrete cytokines, which play critical roles in maintaining homeostasis in the central nervous system (CNS) by mediating the interaction between cells via autocrine or paracrine mechanisms. Circulating cytokines and soluble receptors also regulate neuronal function via endocrine mechanisms. Disturbance of the cytokine-mediated interaction between cells may lead to neuronal dysfunction and/or cell death and contribute to the… CONTINUE READING