Cytokines in rheumatoid arthritis: is it all TNF-alpha?

  title={Cytokines in rheumatoid arthritis: is it all TNF-alpha?},
  author={Pierre Miossec},
  journal={Cellular and molecular biology},
  volume={47 4},
Anti-TNF-alpha therapy has shown clear efficacy in the treatment of rheumatoid arthritis (RA). Since some patients do not respond and the treatment is suspensive, combination therapy may be of interest. Other cytokines produced by monocytes such as IL-1, IL-12, IL-18 are also involved. The secretion of these cytokines is regulated by subsets of T-lymphocytes. Among these, IL-17 producing Th1 cells appear to contribute directly to the destructive process. Furthermore, this T-cell contribution… CONTINUE READING