Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells

@article{Chen2013CytokinesIO,
  title={Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells},
  author={Xiaojia Chen and Jia Lu and Yuhua Ji and A X Hong and Qiuling Xie},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={791-798}
}
Bone is one of the most common metastatic sites for breast cancer. In this study, we observed a promoting effect of osteoblast-conditioned medium (OCM) on the migration of MCF-7, a noninvasive cell line of breast cancer cells. Cytokine antibody array was used to compare the cytokines of OCM with the conditioned medium of non-differentiated osteoblast cells, which consequently revealed factors related to migration, such as IL8, IL6, CSF2 (G-CSF), CSF3 (GM-CSF), and TNFRSF11B (osteoprotegerin… CONTINUE READING

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