Cytokines in cancer pathogenesis and cancer therapy

@article{Dranoff2004CytokinesIC,
  title={Cytokines in cancer pathogenesis and cancer therapy},
  author={Glenn Dranoff},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={11-22}
}
  • G. Dranoff
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Cancer
The mixture of cytokines that is produced in the tumour microenvironment has an important role in cancer pathogenesis. Cytokines that are released in response to infection, inflammation and immunity can function to inhibit tumour development and progression. Alternatively, cancer cells can respond to host-derived cytokines that promote growth, attenuate apoptosis and facilitate invasion and metastasis. A more detailed understanding of cytokine–tumour-cell interactions provides new opportunities… 
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