Cytokines enhance neutrophils from human immunodeficiency virus-negative donors and AIDS patients to inhibit the growth of Mycobacterium avium in vitro.

@article{Newman1997CytokinesEN,
  title={Cytokines enhance neutrophils from human immunodeficiency virus-negative donors and AIDS patients to inhibit the growth of Mycobacterium avium in vitro.},
  author={Gale W Newman and Joseph Guarnaccia and Heinz G. Remold and Powel H Kazanjian},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={175 4},
  pages={
          891-900
        }
}
Mycobacterium avium is one of the most prevalent opportunistic infections in AIDS patients, and neither prophylaxis nor treatment against M. avium is effective. To evaluate host defense mechanisms against mycobacterial infections, studies investigated whether neutrophils from AIDS patients could inhibit the growth of M. avium in vitro and what cytokines enhance neutrophil function against M. avium. Peripheral blood neutrophils from human immunodeficiency virus-negative and AIDS patients were… 
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Neutrophils from AIDS patients treated with granulocyte colony-stimulating factor demonstrate enhanced killing of Mycobacterium avium.
Neutrophils isolated from AIDS patients have demonstrated improved growth inhibition of Mycobacterium avium when incubated with exogenous granulocyte colony-stimulating factor (G-CSF). In this…
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The functional improvement of two critical components of innate antimicrobial immunity, such as neutrophils and monocytes, may contribute to the improved cell-mediated immune responses against opportunistic infections in HAART-treated patients.
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  • Biology, Medicine
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  • 1999
TLDR
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TLDR
Neutrophils play important roles in the host defense against mycobacterial infection, and expression of chemokines interleukin (IL)-8 and macrophage inflammatory protein-1alpha was examined in human blood neutrophils in response to the lipopolysaccharide of Escherichia coli or to Mycobacterium tuberculosis or purified protein derivative.
Neutrophils fromMycobacterium avium-Infected Mice Produce TNF-α, IL-12, and IL-1β and Have a Putative Role in Early Host Response☆
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The results suggest that neutrophils may have a role in the early (innate) immune response against M. avium but it is only evident after acute depletion of neutrophIL and not in mice with chronic neutrophil impairment.
Ethanol suppression of the functional state of polymorphonuclear leukocytes obtained from uninfected and simian immunodeficiency virus infected rhesus macaques.
TLDR
The data demonstrate that the functional state of PMNs from uninfected as well as SIV-infected rhesus macaques is impaired by direct exposure to intoxicating concentrations of ethanol and that this effect can be attenuated by G-CSF.
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