Cytokines enhance airway smooth muscle contractility in response to acetylcholine and neurokinin A.

Abstract

OBJECTIVE In vivo airway hyperresponsiveness has been demonstrated following inhalation of specific cytokines in normal individuals. Whether this airway hyperresponsiveness results from a direct effect of cytokines on airway smooth muscle contractility, or via changes in airway wall structure is not known. The aim of the present study was to determine the… (More)

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