Cytokines associated with pathology in the brain tissue of fatal malaria.

  title={Cytokines associated with pathology in the brain tissue of fatal malaria.},
  author={Yaowapa Maneerat and Emsri Pongponratn and Parnpen Viriyavejakul and Benjanee Punpoowong and Sornchai Looareesuwan and Ratchanee Udomsangpetch},
  journal={The Southeast Asian journal of tropical medicine and public health},
  volume={30 4},
Cytoadherence of Plasmodium falciparum-infected erythrocytes to the brain microvascular endothelial cells is believed to be an important cause of circulatory blockage in cerebral malaria. Cytokines released during acute infection may activate brain endothelial cells leading to increased binding of infected erythrocytes in the brain and reduced cerebral blood flow. This effect may be direct and more potent with the tissue-localized cytokines in the brain. In order to establish this relationship… CONTINUE READING


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