Cytokines as targets in chronic obstructive pulmonary disease.

  title={Cytokines as targets in chronic obstructive pulmonary disease.},
  author={Kian Fan Chung},
  journal={Current drug targets},
  volume={7 6},
Chronic obstructive pulmonary disease [COPD] is characterised by airflow limitation of peripheral airways that is not fully reversible and progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases. There is also intense airway wall remodelling and evidence of systemic inflammation. Increased interleukin [IL]-6, IL-1beta, tumor necrosis factor-alpha [TNF-alpha], GRO-alpha, MCP-1 and IL-8 levels are measured in sputum, with further increases… CONTINUE READING