Cytokines and their receptor complexes.

  title={Cytokines and their receptor complexes.},
  author={D. Roy Davies and A Wlodawer},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={9 1},
The 3-dimensional structures that resulted from X-ray diffraction and nuclear magnetic resonance analyses of a variety of cytokines are reviewed. These proteins form distinct, well-defined superfamilies based on the structures of their monomers, even in the absence of significant sequence homology. However, in several cases, where the active form of a cytokine is a dimer or higher oligomer, these similar monomers adopt very different modes of dimerization. Two examples of complexes of cytokines… CONTINUE READING

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