Cytokines and the activity of the hypothalamus-pituitary-adrenal axis in rats

  title={Cytokines and the activity of the hypothalamus-pituitary-adrenal axis in rats},
  author={M. B. van der Meer},
We investigated the effects of intravenous (i.V.) and intracerebroventricular (i.c.v.) administration of increasing doses of recombinant human IL-1ß, TNFo and IL-6 on plasma corticosterone (В) levels in rats. Rats were equipped with a jugular cannula for repeated blood sampling and a subgroup of rats also received an i.c.v. implanted cannula. I.v. administration of IL-1Ü, TNFo or IL-6 and i.c.v. administration of IL-1ß and IL-6 induced a significant dose-dependent increase in plasma В levels… CONTINUE READING


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