Cytokines and proteoglycans: an introductory overview.

@article{Mulloy2006CytokinesAP,
  title={Cytokines and proteoglycans: an introductory overview.},
  author={Barbara Mulloy and Christopher Barrie Rider},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 3},
  pages={
          409-13
        }
}
The defining characteristic of the glycoproteins known as proteoglycans is the presence of O-linked acidic polysaccharides known as GAGs (glycosaminoglycans). The backbone of these linear polysaccharides is a repeating disaccharide, comprising N-acetyl hexosamine alternating with beta-D-glucuronic acid, alpha-L-iduronic acid, or galactose. For some GAGs, partial deacetylation, epimerization of glucuronic acid, and substitution with N- and O-sulphates result in highly complex, heterogeneous… CONTINUE READING
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