Cytokines and immunodeficiency diseases

  title={Cytokines and immunodeficiency diseases},
  author={W. Leonard},
  journal={Nature Reviews Immunology},
  • W. Leonard
  • Published 2001
  • Biology, Medicine
  • Nature Reviews Immunology
  • Severe combined immunodeficiency disease (SCID) refers to a spectrum of inherited immunodeficiencies that together represent the most severe forms of primary immunodeficiency in humans. Recent work has shown that many of these diseases, as well as other forms of immunodeficiency, result from defects in cytokine signalling pathways. Such defects can prevent normal development of lymphoid lineages and/or compromise cytokine signalling by these cells. These natural 'experiments' in human genetics… CONTINUE READING
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