Cytokines and growth factors in endothelial dysfunction.

  title={Cytokines and growth factors in endothelial dysfunction.},
  author={Allan M. Lefer and Xin-liang Ma},
  journal={Critical care medicine},
  volume={21 2 Suppl},
OBJECTIVE The purpose of this focused review is to call attention to the important interrelationships between growth factors (e.g., transforming growth factor-beta) and cytokines (e.g., tumor necrosis factor [TNF]) on endothelial function as characterized by the ability of the endothelium to release endothelium-derived relaxing factor. BACKGROUND AND METHODS Myocardial ischemia followed by reperfusion leads to a severe degree of endothelial dysfunction characterized by an impaired vasodilator… CONTINUE READING