Cytokines and growth factors in airway remodeling in asthma.

  title={Cytokines and growth factors in airway remodeling in asthma.},
  author={Taylor A. Doherty and David H. Broide},
  journal={Current opinion in immunology},
  volume={19 6},
Airway remodeling in asthma is defined by several structural changes including epithelial cell mucus metaplasia, an increase in peribronchial smooth muscle mass, subepithelial fibrosis, and angiogenesis. Cytokines, chemokines, and growth factors released from inflammatory and structural cells in the airway are considered to play a pivotal role in the development of remodeling. Studies of allergen induced airway remodeling in transgenic mice suggest an important role for TGF-beta, VEGF, Th2… CONTINUE READING

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