Cytokines and depression: the need for a new paradigm.

  title={Cytokines and depression: the need for a new paradigm.},
  author={Lucile Capuron and Robert Dantzer},
  journal={Brain, behavior, and immunity},
  volume={17 Suppl 1},
Considerable clinical and experimental data support the existence of a relationship between cytokines and depression. At the experimental level, proinflammatory cytokines have been found to induce alterations in brain function analogous to the behavioral and biological abnormalities occurring in depressed patients, including social withdrawal, cognitive impairment, anhedonia, increased activity of the hypothalamus-pituitary-adrenal axis, altered neurotransmission, and cross-sensitization with… CONTINUE READING
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