Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi.

@article{Savino2007CytokinesAC,
  title={Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi.},
  author={Wilson Savino and D{\'e}a Maria Serra Villa-Verde and Daniella Ar{\^e}as Mendes-da-Cruz and Eliz{\^a}ngela Silva-Monteiro and Ana R. P{\'e}rez and Maria Pilar Aoki and Oscar Adelmo Bottasso and Natalia Gui{\~n}az{\'u} and Suse Dayse Silva-Barbosa and Susana Gea},
  journal={Cytokine & growth factor reviews},
  year={2007},
  volume={18 1-2},
  pages={107-24}
}
Pathophysiology of Chagas' disease is not completely defined, although innate and adaptative immune responses are crucial. In acute infection some parasite antigens can activate macrophages, and this may result in pro-inflammatory cytokine production, nitric oxide synthesis, and consequent control of parasitemia and mortality. Cell-mediated immunity in Trypanosoma cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be also triggered… CONTINUE READING