Cytokines and acute neurodegeneration

@article{Allan2001CytokinesAA,
  title={Cytokines and acute neurodegeneration},
  author={Stuart M. Allan and Nancy J. Rothwell},
  journal={Nature Reviews Neuroscience},
  year={2001},
  volume={2},
  pages={734-744}
}
Cytokines have been implicated as mediators and inhibitors of diverse forms of neurodegeneration. They are induced in response to brain injury and have diverse actions that can cause, exacerbate, mediate and/or inhibit cellular injury and repair. Here we review evidence for the contribution of cytokines to acute neurodegeneration, focusing primarily on interleukin 1 (IL-1), tumour necrosis factor-α (TNFα) and transforming growth factor-β (TGFβ). TGFβ seems to exert primarily neuroprotective… Expand
Inflammation in central nervous system injury.
  • S. Allan, N. Rothwell
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2003
TLDR
Several anti-inflammatory targets have been identified as putative treatments for CNS disorders, initially in acute conditions, but which may also be appropriate to chronic neurodegenerative conditions. Expand
Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential
TLDR
The naturally occurring IL-1 receptor antagonist (IL-1ra) is currently being considered for treatment of stroke and other disorders. Expand
IL-18: a key player in neuroinflammation and neurodegeneration?
TLDR
A synopsis of the current knowledge of IL-18-dependent mechanisms of action during acute neurodegeneration in immature and adult brains is provided. Expand
Interleukin-1 as a therapeutic target in acute brain injury
TLDR
Evidence supporting the use of rhIL-1RA and other approaches to targeting IL-1 are discussed in relation to cerebral ischemia, seizures, subarachnoid hemorrhage and traumatic brain injury. Expand
T-cell cytokines in injury-induced neural damage and repair
TLDR
The role of interferon-γ, interleukin (IL)-2,IL-4, IL-6, and IL-10 in autoimmune diseases such as multiple sclerosis, and primarily “non-immune” injury of the central nervous system (CNS), in particular focal ischemia and trauma is reviewed. Expand
CNS injury: the role of the cytokine IL-1.
TLDR
Approaches that are being used to investigate neuronal cell death, and the contribution of inflammation and cytokines, in particular the IL-1 family, to neurodegenerative disorders are summarized. Expand
Pro-inflammatory cytokine TNF-alpha as a neuroprotective agent in the brain.
  • I. Figiel
  • Biology, Medicine
  • Acta neurobiologiae experimentalis
  • 2008
TLDR
Different hypotheses pertain to the molecular and cellular effectors triggered by the activation of TNF receptors (TNFRI and TNFR2) focused on diminishing the production of nitric oxide and free radicals, alteration of excitatory amino acids neurotransmission, maintenance of neuronal calcium homeostasis and induction of neurotrophic factors synthesis. Expand
ROLE OF CYTOKINES IN NEURODEGENERATIVE DISEASES
TLDR
Elevated TNF levels in brain and CSF were found in parkinsonian patients which can be attributed the possible basis of neurodegeneration, and expression of various pro-inflammatory mediators including TNF-a,IL-1â, IL-6 has been shown to be closely associated with A4 plaques. Expand
The Function of Cytokines in Ischemic Stroke
TLDR
The timing of intervention will likely be critical in the success of any therapeutic that acts to modulate cytokine signaling within the ischemic microenvironment, and much work is needed to decipher which key signals should be targeted. Expand
Mechanisms of regulation for interleukin-1β in neurodegenerative disease
TLDR
Current evidence on the transcriptional and post-transcriptional regulation of interleukin-1beta production, secretion and activity in the brain and the possible involvement of Toll like receptor-4 is described, including evidence that ischemic brain damage is reduced in Toll like receptors knockout mice. Expand
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References

SHOWING 1-10 OF 194 REFERENCES
Interleukin 1 in the brain: biology, pathology and therapeutic target
TLDR
The mechanisms regulating the expression and action of IL-1 are poorly understood, but involve multiple effects on neuronal, glial and endothelial cell function and provide an attractive and intensely competitive target for therapeutic intervention. Expand
Cytokine signals propagate through the brain
TLDR
It is proposed that cytokine signals propagate along neuronal projections and extracellular diffusion pathways by molecular cascades that need to be further elucidated, a prerequisite for better understanding of reciprocal interactions between nervous, endocrine and immune systems. Expand
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
TLDR
A key role for TNF in injury–induced immune response was demonstrated in TNFR–KO mice, demonstrating that drugs that target TNF signaling pathways may prove beneficial in treating stroke and traumatic brain injury. Expand
TGF-β in the central nervous system: Potential roles in ischemic injury and neurodegenerative diseases
TLDR
TGF-beta has also been shown to play a role in several forms of acute CNS pathology including ischemia, excitotoxicity and several form of neurodegenerative diseases including multiple sclerosis, Parkinson's disease, AIDS dementia and Alzheimer's disease. Expand
Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics
  • F. Barone, G. Feuerstein
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1999
TLDR
The realization that brain ischemia and trauma elicit robust inflammation in the brain provides fertile ground for discovery of novel therapeutic agents for stroke and neurotrauma and inhibition of the mitogen-activated protein kinase (MAPK) cascade via cytokine suppressive anti-inflammatory drugs are most promising new opportunities. Expand
The role of cytokines and growth factors in seizures and their sequelae
TLDR
The experimental evidence supports a role for these factors in each aspect of seizure and pathology, and suggests potential targets for future therapeutics. Expand
Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia
TLDR
Key data are summarized in support for the possibility that inflammatory cells and mediators are important contributing and confounding factors in ischemic brain injury and suggest that novel therapeutic strategies may evolve from detailed research on some specific inflammatory factors. Expand
A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide.
TLDR
It is shown that concentrations of TNF-alpha as low as 10 pg/ml markedly reduce the capacity of IGF-I to promote survival of primary murine cerebellar granule neurons and reveals a novel pathway that leads to neuronal degeneration whereby a proinflammatory cytokine inhibits receptor signaling by a survival peptide. Expand
Cytokines and the nervous system II: actions and mechanisms of action
TLDR
The actions, mechanisms of action and potential strategies for modifying cytokines in the nervous system will be considered in this review, which continues the discussion of cytokine expression and recognition published in the February issue of TINS. Expand
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
TLDR
It is reported that TNF beta and TNF alpha can protect cultured embryonic rat hippocampal, septal, and cortical neurons against glucose deprivation-induced injury and excitatory amino acid toxicity, suggesting a neuroprotective role for TNFs in the brain's response to injury. Expand
...
1
2
3
4
5
...