Cytokines and Their Receptors as Therapeutic Targets

  title={Cytokines and Their Receptors as Therapeutic Targets},
  author={Peter Nickerson},
  • Peter Nickerson
  • Published 2001
  • Biology
  • A major advance in our understanding of the development effector T cells programs came in 1986 when Mosmann and Coffman observed that individual CD4+ T helper (Th) cell clones express phenotypically distinct cytokine profiles [1]. Since then numerous investigators have explored the regulation of these polarized Th cytokine programs, which has given rise to a unifying concept—’the Thl/Th2 paradigm’ (Fig. 1). Central to this paradigm is the role of certain cytokines that act as cross regulators… CONTINUE READING

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