Cytokines and Cognition—The Case for A Head‐to‐Toe Inflammatory Paradigm

  title={Cytokines and Cognition—The Case for A Head‐to‐Toe Inflammatory Paradigm},
  author={Craig J Wilson and Caleb E. Finch and Harvey Cohen},
  journal={Journal of the American Geriatrics Society},
The brain is not only immunologically active of its own accord, but also has complex peripheral immune interactions. Given the central role of cytokines in neuroimmmunoendocrine processes, it is hypothesized that these molecules influence cognition via diverse mechanisms. Peripheral cytokines penetrate the blood‐brain barrier directly via active transport mechanisms or indirectly via vagal nerve stimulation. Peripheral administration of certain cytokines as biological response modifiers… 

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