Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

@article{McLaren2011CytokinesML,
  title={Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.},
  author={James E. McLaren and Daryn R. Michael and Tim G. Ashlin and Dipak P. Ramji},
  journal={Progress in lipid research},
  year={2011},
  volume={50 4},
  pages={331-47}
}
Cardiovascular disease is the biggest killer globally and the principal contributing factor to the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and cholesterol accumulation and the development of fibrotic plaques within the walls of large and medium arteries. Macrophages are fundamental to the immune response directed to the site of inflammation and their normal, protective function is harnessed, detrimentally, in atherosclerosis. Macrophages contribute… CONTINUE READING