Cytokines, for better or worse?

  title={Cytokines, for better or worse?},
  author={Kenneth James Simpson},
  journal={European journal of gastroenterology & hepatology},
  volume={11 9},
Cytokines play an important role in the pathogenesis of many diseases including liver failure. Both newly described and 'classic' pro-inflammatory cytokines, such as tumour necrosis factor-alpha, have been implicated in both hepatic injury and liver regeneration. In addition, increased circulating concentrations of these cytokines suggest they may have a hormone-like endocrine effect on tissues distant to their production, leading to the hypotension, lung injury and cerebral oedema that occur… CONTINUE READING


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