Cytokines, Signal Transduction, and Inflammatory Demyelination: Review and Hypothesis

@article{Ledeen2004CytokinesST,
  title={Cytokines, Signal Transduction, and Inflammatory Demyelination: Review and Hypothesis},
  author={R. Ledeen and G. Chakraborty},
  journal={Neurochemical Research},
  year={2004},
  volume={23},
  pages={277-289}
}
The mechanism of focal demyelination in multiple sclerosis has been a long-standing enigma of this disorder. Cytokines, a diverse family of signalling molecules, are viewed as potential mediators of the process based on clinical observations and studies with animal models and tissue/cell culture systems. Myelin and oligodendrocyte (OL) destruction occur in cultured preparations subjected to cytokines such as tumor necrosis factor-α (TNFα) and lymphotoxin (LT). Many studies have shown these and… Expand
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