Cytokine transcriptional events during helper T cell subset differentiation

@article{Lederer1996CytokineTE,
  title={Cytokine transcriptional events during helper T cell subset differentiation},
  author={James A. Lederer and V{\'i}ctor L. P{\'e}rez and Louis-Benoit Desroches and Seok Mo Kim and Abul K Abbas and Andrew H. Lichtman},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={397 - 406}
}
The molecular basis for changes in cytokine expression during T helper (Th) cell subset differentiation is not well understood. We have characterized transcriptional events related to cytokine gene expression in populations of naive T cell receptor-transgenic T cells as they are driven in vitro toward Th1 or Th2 phenotypes by interleukin (IL)-12 or IL-4 treatment, respectively. Quantitative reverse transcriptase-polymerase chain reaction analysis of cytokine transcripts indicates that… CONTINUE READING
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