Cytokine transcriptional events during helper T cell subset differentiation

  title={Cytokine transcriptional events during helper T cell subset differentiation},
  author={James A. Lederer and V{\'i}ctor L. P{\'e}rez and Louis-Benoit Desroches and Seok Mo Kim and Abul K Abbas and Andrew H. Lichtman},
  journal={The Journal of Experimental Medicine},
  pages={397 - 406}
The molecular basis for changes in cytokine expression during T helper (Th) cell subset differentiation is not well understood. We have characterized transcriptional events related to cytokine gene expression in populations of naive T cell receptor-transgenic T cells as they are driven in vitro toward Th1 or Th2 phenotypes by interleukin (IL)-12 or IL-4 treatment, respectively. Quantitative reverse transcriptase-polymerase chain reaction analysis of cytokine transcripts indicates that… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 67 extracted citations

Immunomodulatory effects of transforming growth factor-β in the liver.

Hepatobiliary surgery and nutrition • 2014
View 13 Excerpts
Highly Influenced

Exosomes as a tumor immune escape mechanism: possible therapeutic implications

Journal of Translational Medicine • 2008
View 5 Excerpts
Highly Influenced

Beneficial autoimmunity participates in the regulation of rheumatoid arthritis.

Frontiers in bioscience : a journal and virtual library • 2006
View 14 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 30 references

Nature (Lond.). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

K. Shimoda, J. Deursen, +11 authors J. N. Ihle
View 1 Excerpt

Similar Papers

Loading similar papers…