Cytokine toxicity to oligodendrocyte precursors is mediated by iron.

  title={Cytokine toxicity to oligodendrocyte precursors is mediated by iron.},
  author={Xuesheng Zhang and Michael Haaf and Bozho M Todorich and Erin Grosstephan and Henry Schieremberg and Nodar Surguladze and James R. Connor},
  volume={52 3},
Inflammatory processes play a key role in the pathogenesis of a number of common neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Abnormal iron accumulation is frequently noted in these diseases and compelling evidence exists that iron is involved in inflammatory reactions. Histochemical stains for iron repeatedly demonstrate that oligodendrocytes, under normal conditions, stain more prominently than any other cell type in the… CONTINUE READING
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