Cytokine therapeutics for the treatment of sepsis: why has nothing worked?

Abstract

Several clinical trials have attempted to treat sepsis by blocking certain aspects of the inflammatory response. Tumor necrosis factor and interleukin 1 have been specific targets for inhibition but none of the trials have been successful. These trials were started on the basis of preclinical trials that suggested these would be effective. There were three… (More)

Topics

Cite this paper

@article{Remick2003CytokineTF, title={Cytokine therapeutics for the treatment of sepsis: why has nothing worked?}, author={Daniel G Remick}, journal={Current pharmaceutical design}, year={2003}, volume={9 1}, pages={75-82} }