Cytokine therapeutics: lessons from interferon alpha.

  title={Cytokine therapeutics: lessons from interferon alpha.},
  author={Jordan U. Gutterman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 4},
Cytokines are soluble proteins that allow for communication between cells and the external environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. This review focuses on the biological and clinical activities of the cytokine. Originally discovered as an antiviral substance, the… CONTINUE READING
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