Cytokine targeting in psoriasis and psoriatic arthritis: beyond TNFalpha.

  title={Cytokine targeting in psoriasis and psoriatic arthritis: beyond TNFalpha.},
  author={I B MclInnes},
  journal={Ernst Schering Research Foundation workshop},
  • I B MclInnes
  • Published 2006 in Ernst Schering Research Foundation workshop
Targeting TNFalpha provided proof of concept for the role of pro-inflammatory cytokines in promoting cutaneous inflammation, particularly psoriasis. Recent studies have elucidated the presence of numerous cytokine and chemokine activities in psoriatic skin and synovium. There is considerable interest in the potential of such activities as novel therapeutic targets. IL-15 is an innate response cytokine that activates leukocyte subsets via binding to its unique IL-15Ralpha and shared beta and… CONTINUE READING


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