Cytokine storm and sepsis disease pathogenesis

  title={Cytokine storm and sepsis disease pathogenesis},
  author={Benjamin G. Chousterman and Filip K Swirski and Georg F Weber},
  journal={Seminars in Immunopathology},
Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical syndrome related to the host response to infection. The severity of infections is due to an activation cascade that will lead to an autoamplifying cytokine production: the cytokine storm. Cytokines are a broad category of relatively small proteins (<40 kDa) that are produced and released with the aim of cell signaling. Our understanding of the processes that trigger this tremendous amount of cytokine… CONTINUE READING

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