Cytokine-stimulated nitric oxide production in the human renal proximal tubule and its modulation by natriuretic peptides: A novel immunomodulatory mechanism?

@article{Chatterjee1999CytokinestimulatedNO,
  title={Cytokine-stimulated nitric oxide production in the human renal proximal tubule and its modulation by natriuretic peptides: A novel immunomodulatory mechanism?},
  author={Prabal Kumar Chatterjee and Gabrielle M.. Hawksworth and James S McLay},
  journal={Experimental nephrology},
  year={1999},
  volume={7 5-6},
  pages={
          438-48
        }
}
Although the importance of the human kidney in a variety of disease states is well recognised, the exact mechanisms involved remain unclear. Animal disease models suggest that while high local concentrations of nitric oxide (NO) may play a key role in the initiation and progression of renal disease, low levels may also be essential for normal renal function and cell protection, possibly explaining the variable reports of both beneficial and detrimental responses of renal disease models… CONTINUE READING
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