Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.

@article{Spirl2003CytokinestimulatedNO,
  title={Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.},
  author={Carlo Spirl{\'i} and Luca Fabris and Elena Duner and Romina Fiorotto and Giorgio Ballardini and Tania A Roskams and Nicholas F. LaRusso and Aurelio Sonzogni and Lajos Okolicsanyi and Mario Strazzabosco},
  journal={Gastroenterology},
  year={2003},
  volume={124 3},
  pages={737-53}
}
BACKGROUND & AIMS The biliary epithelium is involved both in bile production and in the inflammatory/reparative response to liver damage. Recent data indicate that inflammatory aggression to intrahepatic bile ducts results in chronic progressive cholestasis. METHODS To understand the effects of nitric oxide on cholangiocyte secretion and biliary tract pathophysiology we have investigated: (1) the effects of proinflammatory cytokines on NO production and expression of the inducible nitric… CONTINUE READING

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