Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine.

@article{Yeh2000CytokinestimulatedBN,
  title={Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine.},
  author={Meiling Yeh and Marcus Kaul and Jialin C Zheng and Hans S L M Nottet and Michael R. Thylin and Howard E. Gendelman and Stuart Lipton},
  journal={Journal of immunology},
  year={2000},
  volume={164 8},
  pages={4265-70}
}
Approximately one-quarter of individuals with AIDS develop neuropathological symptoms that are attributable to infection of the brain with HIV. The cognitive manifestations have been termed HIV-associated dementia. The mechanisms underlying HIV-associated neuronal injury are incompletely understood, but various studies have confirmed the release of neurotoxins by macrophages/microglia infected with HIV-1 or stimulated by viral proteins, including the envelope glycoprotein gp120. In the present… CONTINUE READING
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