Cytokine-specific regulation of urokinase receptor (CD87) expression by U937 mononuclear phagocytes.

@article{Sitrin1994CytokinespecificRO,
  title={Cytokine-specific regulation of urokinase receptor (CD87) expression by U937 mononuclear phagocytes.},
  author={Robert G. Sitrin and Robert F. Todd and Ikuko F. Mizukami and Thomas J. Gross and S B Shollenberger and Margaret R. Gyetko},
  journal={Blood},
  year={1994},
  volume={84 4},
  pages={
          1268-75
        }
}
Mononuclear phagocytes concentrate urokinase-type plasminogen activator (uPA) at the cell surface by expressing membrane uPA receptors (uPAR). This study examines the ability of exogenous cytokines to alter expression of membrane-associated uPA and uPAR in U937 mononuclear phagocytes. Cells were stimulated with recombinant interferon gamma (IFN gamma) or tumor necrosis factor alpha (TNF alpha), followed by immunolabeling for uPA or uPAR and flow cytometry. IFN gamma increased surface uPA 2.2… CONTINUE READING

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