Cytokine signalling in human melanoma cells determines susceptability to statin-induced apoptosis

Abstract

Background Melanoma is one of the most aggressive and chemoresistant cancer types in humans. Especially in late stages, effective therapeutic approaches are not available. Statins have been investigated for their anti-proliferative and proapoptotic effects in many tumor cells including melanoma [1]. Beside paracrine signalling, melanoma cells rely on a wide… (More)

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