Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

@article{Yu2006CytokineST,
  title={Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection},
  author={Qing Yu and Jung-Hyun Park and Loretta L. Doan and Batu Erman and L. Feigenbaum and Alfred Singer},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={165 - 175}
}
Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We report that DP thymocytes before positive selection (preselection DP thymocytes) fail to transduce IL-7 signals even when they express high levels of transgenic IL-7R on their surface, because IL-7R signal transduction is actively suppressed in preselection DP thymocytes by suppressor of cytokine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…