Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion.

@article{Krishnaraj1996CytokineSO,
  title={Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion.},
  author={Rajabather Krishnaraj and T Bhooma},
  journal={Immunology letters},
  year={1996},
  volume={50 1-2},
  pages={59-63}
}
A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been examined before. In view of the major immunomodulatory role of IL2 and the anti-tumor effects of interferon gamma (IFN-gamma), we have investigated the recombinant human IL2-induced NK… CONTINUE READING
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