Cytokine responses to novel antigens in a peri-urban population in Brazil exposed to Leishmania infantum chagasi.

@article{Stober2012CytokineRT,
  title={Cytokine responses to novel antigens in a peri-urban population in Brazil exposed to Leishmania infantum chagasi.},
  author={Carmel B. Stober and Selma M B Jeronimo and N{\'u}bia N. Pontes and E Nancy Miller and Jenefer M Blackwell},
  journal={The American journal of tropical medicine and hygiene},
  year={2012},
  volume={87 4},
  pages={663-70}
}
Visceral leishmaniasis (VL) is fatal if untreated, and there are no vaccines for this disease. High levels of CD4-derived interferon-γ (IFN-γ) in the presence of low levels of interleukin-10 (IL-10) predicts vaccine success. Tumor necrosis factor-α (TNF-α) is also important in this process. We characterized human immune responses in three groups exposed to Leishmania infantum chagasi in Brazil: 1) drug-cured VL patients (recovered VL); 2) asymptomatic persons with positive Leishmania-specific… CONTINUE READING

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