Cytokine response of primary human myotubes in an in vitro exercise model.

  title={Cytokine response of primary human myotubes in an in vitro exercise model.},
  author={Mika Scheler and Martin Irmler and Stefan Lehr and Sonja Hartwig and Harald Staiger and Hadi Al-Hasani and Johannes Beckers and Martin Hrabe de Angelis and Hans-Ulrich H{\"a}ring and Cora Weigert},
  journal={American journal of physiology. Cell physiology},
  volume={305 8},
Muscle contraction during exercise is a major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the beneficial adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes enables the investigation of the molecular response to exercise in a clearly defined model. We applied EPS for 24 h to primary human myotubes and studied the whole genome-wide transcriptional response… CONTINUE READING
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A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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  • Nature 481:
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