Cytokine regulation of secondary lymphoid organ development.

  title={Cytokine regulation of secondary lymphoid organ development.},
  author={David D. Chaplin and Yang-Xin Fu},
  journal={Current opinion in immunology},
  volume={10 3},
Lymphotoxin and tumor necrosis factor provide essential signals for the formation of secondary lymphoid tissue structures. Lymphotoxin in its membrane form (LT alpha 1 beta 2 heterotrimer) is required for the development of lymph nodes and Peyer's patches and supports the development of normal spleen structure. In the spleen, lymphotoxin acts during embryonic development to support the formation of distinct B and T cell zones. Lymphotoxin also acts in a tonic fashion-supporting the formation… CONTINUE READING


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