Cytokine regulation of pulmonary fibrosis in scleroderma.

  title={Cytokine regulation of pulmonary fibrosis in scleroderma.},
  author={Sergei P. Atamas and Barbara W White},
  journal={Cytokine & growth factor reviews},
  volume={14 6},
Pulmonary fibrosis occurs in up to 70% of scleroderma patients and progresses to cause severe restrictive lung disease in about 15% of patients. The mechanisms that cause pulmonary fibrosis in scleroderma remain incompletely understood. Increased amounts of mRNA or protein for multiple profibrotic cytokines and chemokines have been identified in lung tissue or broncholveolar lavage samples from scleroderma patients, when compared to healthy controls. These cytokines include transforming growth… CONTINUE READING
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