Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.

Abstract

Chemotaxis is essential for shaping immune responses and chemokine-receptor antagonists are now being evaluated as therapies for various inflammatory and autoimmune diseases. However, the dysregulation of chemotaxis in autoimmune disease may involve both promotion and inhibition of B-cell migration. This review focuses on the disparate mechanisms by which… (More)

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@article{Mountz2011CytokineRO, title={Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.}, author={John D. Mountz and John C. H. Wang and Shutao Xie and Hui-Chen Hsu}, journal={Discovery medicine}, year={2011}, volume={11 56}, pages={76-85} }