Cytokine receptors and hematopoietic differentiation

  title={Cytokine receptors and hematopoietic differentiation},
  author={Lorraine Robb},
Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in lineage specification in hematopoiesis. An alternative to this instructive hypothesis is the stochastic or permissive hypothesis. The latter proposes that commitment to a… CONTINUE READING