Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.

@article{Chen2017CytokineRS,
  title={Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.},
  author={Jing Chen and Yong Zhang and Michael N. Petrus and Wenming Xiao and Alina Nicolae and Mark A. Raffeld and Stefania Pittaluga and Richard N. Bamford and Masao Nakagawa and Sunny Tianyi Ouyang and Alan L. Epstein and Marshall Edward Kadin and Annarose Del Mistro and Richard D Woessner and Elaine S. Jaffe and Thomas A. Waldmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 15},
  pages={3975-3980}
}
Activating Janus kinase (JAK) and signal transducer and activator of transcription (STAT) mutations have been discovered in many T-cell malignancies, including anaplastic lymphoma kinase (ALK)- anaplastic large cell lymphomas (ALCLs). However, such mutations occur in a minority of patients. To investigate the clinical application of targeting JAK for ALK- ALCL, we treated ALK- cell lines of various histological origins with JAK inhibitors. Interestingly, most exogenous cytokine-independent cell… CONTINUE READING
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