Cytokine profile in two siblings with neonatal lupus erythematosus.

  title={Cytokine profile in two siblings with neonatal lupus erythematosus.},
  author={Hironori Shimozawa and Yumi Kono and Miyuki Matano and Yume Suzuki and Yasunori Koike and Yukari Yada and Takanori Yamagata and Naoto Takahashi},
  journal={Pediatrics international : official journal of the Japan Pediatric Society},
  volume={57 6},
We studied the cytokine profile of two siblings with neonatal lupus erythematosus (NLE) born to a mother positive for serum anti-Ro and -La antibodies, who did not receive any medication during the two pregnancies. The first sibling was found to have complete atrioventricular block in utero and became severely ill after birth. He fulfilled the diagnostic criteria for hemophagocytic lymphohistiocytosis on day 2. The second sibling did not have any fetal symptoms. He was generally stable after… CONTINUE READING