Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy.

@article{AndresHernando2012CytokinePI,
  title={Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy.},
  author={Ana Andres-Hernando and Belda Dursun and Christopher J. Altmann and Nilesh H Ahuja and Zhibin He and Rhea Bhargava and Charles E Edelstein and Alkesh H Jani and Thomas S Hoke and Christina Klein and Sarah Faubel},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2012},
  volume={27 12},
  pages={4339-47}
}
  • Ana Andres-Hernando, Belda Dursun, +8 authors Sarah Faubel
  • Published 2012 in
    Nephrology, dialysis, transplantation : official…
  • DOI:10.1093/ndt/gfs256
BACKGROUND Serum cytokines are increased in patients with acute kidney injury (AKI) and predict increased mortality. It is widely assumed that increased renal production of cytokines is the source of increased serum cytokines; the role of extra-renal cytokine production and impaired renal cytokine clearance is less well studied. We hypothesized that cytokine production in AKI was mononuclear phagocyte dependent, independent of production by the kidneys, and that serum cytokine clearance would… CONTINUE READING

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