Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women.

@article{Kassem1996CytokinePI,
  title={Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women.},
  author={Moustapha Kassem and Sundeep Khosla and Thomas C. Spelsberg and B. Lawrence Riggs},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 2},
  pages={513-8}
}
Recent studies in rodents and in human in vitro systems suggest that the action of estrogen on bone is modulated by various bone-resorbing cytokines produced by osteoblasts, bone marrow cells, or both, but results among studies have been conflicting. Thus, we studied 20 untreated women (controls) and 20 women who had received estrogen replacement therapy since the time of menopause; both groups were 5 +/- 1 yr (mean +/- SE) postmenopausal. From bone marrow aspirates, we obtained marrow plasma… CONTINUE READING

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