Cytokine production in Linomide-treated nod mice and the potential role of a Th (1)/Th(2) shift on autoimmune and anti-inflammatory processes.

@article{Weiss2002CytokinePI,
  title={Cytokine production in Linomide-treated nod mice and the potential role of a Th (1)/Th(2) shift on autoimmune and anti-inflammatory processes.},
  author={Lola Weiss and Vivian Barak and Michael Zeira and Ali Abdul-Hai and Israel Raibstein and Shoshana Reich and Esther Hirschfeld and David Gross and Shimon Slavin},
  journal={Cytokine},
  year={2002},
  volume={19 2},
  pages={85-93}
}
Linomide prevents the development of autoimmune insulitis and insulin-deficient diabetes mellitus in female NOD mice. Linomide prevents development of autoimmune manifestations in other experimentally induced and spontaneous autoimmune diseases as well, but the mechanism of action is unknown. The present report summarizes our investigations on the effect of Linomide on different functional T cell subsets in NOD mice analyzed according to their cytokine profile. Supernatants from cultured… CONTINUE READING