Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo.

@article{Kawagishi2001CytokinePB,
  title={Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo.},
  author={C. Kawagishi and Kahori Kurosaka and Naoko Watanabe and Yoshiro Kobayashi},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1541 3},
  pages={221-30}
}
Chemotherapy and radiotherapy are performed for cancer patients with the hope that dying cancer cells are safely scavenged by phagocytic cells such as macrophages. In this study, we examined cytokine production by macrophages during and after the phagocytosis of etoposide-treated P388 cells in vitro and in vivo. Etoposide caused apoptosis as early as 5 h after treatment, as assessed as to the exposure of phosphatidylserine, increase in membrane permeability and DNA ladder formation… CONTINUE READING

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