Corpus ID: 22663003

Cytokine production by activated T cells in common variable immunodeficiency.

@article{Rezaei2010CytokinePB,
  title={Cytokine production by activated T cells in common variable immunodeficiency.},
  author={N. Rezaei and A. Aghamohammadi and M. Nourizadeh and G. Kardar and Z. Pourpak and A. Zare and R. Read},
  journal={Journal of investigational allergology \& clinical immunology},
  year={2010},
  volume={20 3},
  pages={
          244-51
        }
}
BACKGROUND Common variable immunodeficiency (CVID) is the most common symptomatic antibody deficiency. It is characterized by hypogammaglobulinemia, increased susceptibility to recurrent infections, autoimmunity, and malignancies. OBJECTIVES To determine whether patients with CVID have cytokine production defects after T-cell activation and to assess whether or not these are correlated with markers of severe disease. METHODS Twenty-seven patients with CVID and 17 healthy volunteers were… Expand
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TLDR
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An imbalance between costimulatory molecules expression (CD28, CD40L/CD154 and CTLA‐4/CD152) and cytokine production by T cells does not explain a deficient cooperation between T and B cells in this group of CVID patients. Expand
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